R. Fadini - IVF Research Network

Dr. Rubens Fadini, graduated with honours in Medicine and Surgery at the University of Milan, is a specialist in obstetrics and gynecology since 1982, and a specialist in Human reproduction in 1987 at the University of Milan.
He was a pioneer in practice Artificial Reproduction and from 1985 to 1999 he directed the Unit of Reproductive Medicine Endocrinology at S. Gerardo University Hospital in Monza, University of Milan.
Since 2000 he is Founder and Chief of the BIOGENESI Reproductive Medicine Centres.
He is Assistant Professor at the School of Specialization in “Gynaecology and Obstetrics” and at the School of Medical Biotechnologies -Faculty of Medicine- of the University of Milan-Bicocca.
Currently he is taking part of several clinical and biological research projects on optimizing the ovarian stimulation protocols for Assisted Reproductive Technologies. Current research interests include new strategies for fertility preservation and endometrial physiology and receptivity.
He delivered lectures in many national and international conferences, produced an extensive range of scientific publications and act as a regular reviewer for reproduction journals (Fertility & Sterility, Human Reproduction, RBMO, JARG).

Publications

Clinical outcomes from mature oocytes derived from preovulatory and antral follicles: reflections on follicle physiology and oocyte competence.

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Claudio Brigante,.
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J Assist Reprod Genet. 2014

Oocyte in vitro maturation in normo-ovulatory women.

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A. Epis,.
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I. Caliari,.
Claudio Brigante,.
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Fertility and Sterility- 2013 -99(5):1162-9.

Mechanistic foundations of the metaphase II spindle of human oocytes matured in vivo and in vitro

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Human Reproduction.-2013, 28(12):3271-82.

Contributions of the actin cytoskeleton to the emergence of polarity during maturation in human oocytes.

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Molecular Human Reproduction.-2013, doi:10.1093/MOLEHR/GAT085

The current challenges to efficient immature oocyte cryopreservation.

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Journal of Assisted Reproduction and Genetics- 2013 Oct – DOI 10.1007/s10815-013-0112-0

LH-Receptor Gene Expression in Human Granulosa and Cumulus Cells from Antral and Preovulatory Follicles

J.V. Jeppesen,.
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K.T. Schmidt,.
E. Ernst,.
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2012 J. Clin. Endocrinol. Metab.

DNA double strand breaks are associated with meiotic resumption failure in human GV-stage oocytes

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Human Reproduction – 2012- 27 Suppl. 1, i189.

Comparison of the obstetric and perinatal outcomes of children conceived from in vitro or in vivo matured oocytes in in vitro maturation treatments with births from conventional ICSI cycles.

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A. Sutcliffe,.
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Human Reproduction – 2012- 27, 3601–3608.

Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer.

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Journal of Assisted Reproduction and Genetics – 2012- 29, 779–781.

Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation.

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Reproductive Biomedicine Online -2012- 25, 474–480.

Cumulus cell-oocyte complexes retrieved from antral follicles in IVM cycles: relationship between COCs morphology, gonadotropin priming and clinical outcome.

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Journal of Assisted Reproduction and Genetics -2012- 29, 513–519.

Human oocyte maturation in vitro

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Int. J. Dev. Biol.- 2012- 56, 909–918.

Time-lapse imaging of immature human oocytes reveals a role for the oocyte cortex in germinal vesicle anchoring and meiotic resumption

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Human Reproduction -2011- Vol. 26, Supplement 1--P176

In vitro maturation does not affect the geometry of the metaphase II spindle and cortical actin polarization of human oocytes

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Human Reproduction - 2011 -Vol. 26, Supplement 1-P136-

New effective approach to blastocyst culture based on use of blastocyst medium from late day 2 of development.

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M. Merola,.
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Human Reproduction -2011- Vol. 26, Supplement 1- P123

Time-lapse videomicroscopy as a tool to predict the development of human embryos to the blastocyst stage

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Molecular Human Reproduction -2011- od PMID 21307090

Expression and Regulation of sFRP Family Members in Human Granulosa Cells.

E. Maman,.
Y. Yung,.
J. Cohen,.
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H. Kanety,.
A. Kadem,.
J. Dor,.
A. Hourvitz,.

Molecular Human Reproduction -2011- od PMID 21307090

Anti_Mullerian hormone remains higly expressed in human cumulus celles during the final stage of folliculogenesis

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I.A. Rasmussen,.
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S.G. Kristensen,.
C. Yding Andersen,.

Reproductive Biomedicine Online – 2011- 22, 389-398

Outcome of cycles of oocyte in vitro maturation requiring testicular sperm extraction for non-obstructive azoospermia.

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Fertility and Sterility – 2011- 96, 321–323

Anti-Mullerian hormone as a predictive marker to select women for in vitro maturation treatment

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Journal of Assisted Reproduction and Genetics - 2011 - 28, 501–508

Perinatal outcome of 120 children born from oocyte in vitro maturation treatment

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Human Reproduction -2010- 25 (suppl. 1, i243).

High survival rate after vitrification at the germinal vesicle stage of human oocytes from in vitro maturation cycles.

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Human Reproduction -2010- 25 (Suppl. 1), i270

Adamts-1 : a new human ovulatory gene and a cumulus marker for fertilization capacity

Y. Yung,.
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S. Konopnicki,.
Cohen B.,.
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Molecular and Cellular Endocrinology – 2010- 26; 328 (1-2):104-8 Oct. 2

Predictive factors in in-vitro maturation in unstimultated women with normal ovaries.

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Milani R.,.
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Reproductive BioMedicine Online -2009-Vol.18, No 2, 2009, 251-261

Effect of different gonadotrophin priming on IVM of oocytes in women with normal ovaries: a prospective randomized study.

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Milani R.,.
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Reproductive BioMedicine Online -2009-19, 343-351

Human oocyte cryopreservation: comparison between slow and ultra-rapid methods.

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Reproductive BioMedicine Online -2009-19, 171-180

Production of sHLA-G molecules by in vitro matured cumulus-oocyte complex

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International Journal Of Molecular Medicine -2009- 24, 523-530

The number of oocytes collected and matured affect IVM success –

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Human Reproduction -2005-. 20(suppl 1): i119 (P-326)

Differential regulation of cumulus cell transcription during oocyte maturation in vivo and in vitro.

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Int J Dev Biol. 2017;61(6-7):433-437.

Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability.

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Hum Reprod 2017;33:23–31

Retrospective analysis of treatments with recombinant FSH and recombinant LH versus human menopausal gonadotropin in women with reduced ovarian reserve.

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J Assist Reprod Genet. 2017 Sep 4. doi: 10.1007/s10815-017-1034-z.

Dismorphic patters are associated with cytoskeletal alterations in human oocyte.

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Hum Reprod. 2017 Apr 1;32(4):750-757.

Ultrastructure of human oocytes after in vitro maturation.

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Mol Hum Reprod. 2016 Feb;22(2):110-8. doi: 10.1093/molehr/gav071

Morphokinetics of embryos developed from oocytes matured in vitro

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J. Assist Reprod Genet. 2016 Feb;33(2):247-53. doi: 10.1007/s10815-015-0625-9

Double-strand DNA breaks and repair response in human immature oocytes and their relevance to meiotic resumption.

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J. Assist Reprod Genet. 2015 Oct;32(10):1509-16. doi: 10.1007/s10815-015-0547-6

Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization.

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Hum Reprod Update. 2015 Jul-Aug;21(4):427-54. doi: 10.1093/humupd/dmv011. Review.

Clinical outcomes from mature oocytes derived from preovulatory and antral follicles: reflections on follicle physiology and oocyte competence.

R. Fadini,.
G. Coticchio,.
F. Brambillasca,.
M. Mignini,.
P.V. Novara,.
Claudio Brigante,.
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J. Assist Reprod Genet. 2015 Feb;32(2):255-61. doi: 10.1007/s10815-014-0386-x.

Characterization of the human cumulus cell transcriptome during final follicular maturation and ovulation.

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Molecular Human Reproduction -2014. doi: 10.1093/molehr/gau031

Natriuretic peptide precursor C delays meiotic resumption and sustains gap junction-mediated communication in bovine cumulus-enclosed oocytes.

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Biol Reprod. 2014 Sep;91(3):61. doi: 10.1095/biolreprod.114.118869.

Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability

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Hum Reprod 2017;33:23–31